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Tarkio (pop. 1,494) is located at the intersection of Hwy. 59 and Hwy. 136, seven miles off of I-29.  Tarkio is home to the former Tarkio Tech (formerly Tarkio College) and Heartland Recreation Center, and boasts a number of historic homes.  Active community groups include Tarkio Chamber of Commerce, and Tarkio Rotary.  Tarkio R-I (K-12) cooperates with Fairfax as the East Atchison Wolves for athletics.

Tarkio Renewal, a 501(c)3 organization established in 2006, is a group of community volunteers whose focus is the elimination of dangerous and dilapidated buildings and general beautification of the community.  If you would like to give a tax-deductible donation to this group, please send your contribution to P.O. Box 243, Rock Port, MO 64482 or drop off at Farmers State Bank (512 Main St., Tarkio, MO 64491).